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GLYARK-M

Brand Name : GLYARK-M

Packing : 10*15

Composition : Gliclazide 80MG Metformine (SR) 500MG TABLET

GLYARK-M

 


 

Gliclazide Metformin (SR) Tablet: Overview

Gliclazide Metformin (SR) Tablets is an oral medication used to treat Type 2 diabetes mellitus. It is a combination of two active ingredients: Gliclazide and Metformin. This combination is often formulated as sustained-release (SR) tablets, allowing for slower absorption of the drug, leading to prolonged blood sugar control throughout the day. The two medications complement each other in their mechanisms, providing a comprehensive approach to lowering blood glucose levels.

Gliclazide belongs to the class of drugs known as sulfonylureas. It stimulates the pancreas to produce more insulin, which helps lower blood sugar.

Metformin on the other hand, is part of the biguanide class of drugs. It reduces glucose production in the liver and improves insulin sensitivity, thereby helping cells take in glucose more effectively.

The combination of these two medications in a single tablet is particularly useful for patients who require a more aggressive approach to controlling their blood sugar levels, especially when lifestyle modifications like diet and exercise alone are not sufficient.

How Does Gliclazide Metformin (SR) Tablet Work?

The two components of this combination tablet work synergistically to regulate blood sugar levels:

1. Gliclazide’s Mechanism of Action:

Stimulates Insulin Secretion: Gliclazide works primarily by stimulating the beta cells in the pancreas to produce more insulin. This is important in Type 2 diabetes, where insulin production is often inadequate or the body's cells have become resistant to insulin.

Prolonged Action: Because it stimulates insulin secretion throughout the day, it helps maintain a more stable blood glucose level, reducing both fasting and postprandial (after meals) blood sugar levels.

2. Metformin’s Mechanism of Action:

Reduces Hepatic Glucose Production: Metformin decreases the liver’s production of glucose, a process known as gluconeogenesis. This is particularly useful in Type 2 diabetes, where the liver often produces too much glucose, contributing to elevated blood sugar levels.

Improves Insulin Sensitivity: Metformin enhances the sensitivity of peripheral tissues (muscles and fat cells) to insulin. This allows cells to use glucose more efficiently, reducing blood sugar levels.

Slows Carbohydrate Absorption: Metformin also delays the absorption of carbohydrates from the intestines, reducing postprandial blood glucose spikes.

Sustained Release (SR) Formulation:

The sustained-release (SR) formulation means that the medication is slowly released into the bloodstream over time, allowing for a more consistent therapeutic effect and reducing the need for multiple daily doses. This improves patient adherence and minimizes fluctuations in blood sugar levels.

Uses of Gliclazide Metformin (SR) Tablet

The primary indication of Gliclazide Metformin (SR) tablets is for managing Type 2 diabetes mellitus in adults. It is particularly useful in patients where blood sugar levels are not adequately controlled by lifestyle changes alone or with a single oral antidiabetic medication. Specific uses include:

1. Improvement of Glycemic Control: The combination tablet is used to improve overall glycemic control by targeting both fasting and postprandial glucose levels. Gliclazide works immediately to stimulate insulin production, while Metformin provides background control by reducing glucose production and enhancing insulin sensitivity.

2. Combination Therapy: Gliclazide Metformin (SR) is often used as part of a combination therapy approach. In some cases, it may be used alongside other oral antidiabetic drugs, such as SGLT-2 inhibitors or DPP-4 inhibitors, to achieve optimal glucose control. It may also be used in combination with insulin.

3. Reduction of Complications: By maintaining better glycemic control, Gliclazide Metformin (SR) helps reduce the risk of long-term complications associated with diabetes, such as diabetic nephropathy, retinopathy, neuropathy, and cardiovascular disease.

4. Obese or Overweight Patients: Metformin in the combination is particularly useful for overweight or obese patients with Type 2 diabetes because, unlike other diabetes medications, it does not promote weight gain. In some cases, Metformin may even help with modest weight loss.

Benefits of Gliclazide Metformin (SR) Tablet

The Pharma Franchise for Gliclazide Metformin (SR) Tablets combination offers several benefits that make it an effective and preferred treatment option for Type 2 diabetes:

Broad Spectrum of Action:

1. Dual Action for Better Glycemic Control: The combination of Gliclazide and Metformin provides a more comprehensive approach to managing blood sugar levels. While Gliclazide works by increasing insulin secretion, Metformin reduces glucose production and improves insulin sensitivity. This dual mechanism helps achieve more effective and balanced glycemic control.

2. Reduces the Risk of Hypoglycemia: Although sulfonylureas like Gliclazide can sometimes cause hypoglycemia, the risk is lower when combined with Metformin, which is less likely to cause low blood sugar. The sustained-release formulation further reduces this risk by maintaining more stable blood sugar levels throughout the day.

3. Improved Insulin Sensitivity: Metformin helps improve the body’s sensitivity to insulin, meaning the cells can better use the insulin that is already available. This reduces the need for the pancreas to work harder to produce more insulin, potentially preserving beta-cell function in the long term.

4. Weight Neutrality or Weight Loss: One of the major benefits of Metformin is that it does not promote weight gain, unlike many other antidiabetic drugs. In some patients, Metformin can even help with modest weight loss, making it particularly beneficial for overweight or obese individuals with Type 2 diabetes.

5. Lower Risk of Cardiovascular Disease: Metformin has been shown to reduce the risk of cardiovascular complications in patients with Type 2 diabetes. The combination tablet helps manage risk factors such as high blood sugar and insulin resistance, which contribute to heart disease and stroke.

6. Simplified Dosing with SR Formulation: The sustained-release formulation means that patients can take the medication less frequently, usually just once a day. This simplifies the treatment regimen and improves patient adherence, ensuring more consistent blood sugar control.

7. Better Long-term Diabetes Management: The combination of Gliclazide and Metformin addresses multiple pathways involved in blood sugar control. This makes the medication a strong choice for long-term diabetes management, as it helps prevent complications and maintains better glycemic control over time.

8. Potential for Combination with Other Drugs: Gliclazide Metformin (SR) tablets can be combined with other antidiabetic medications when necessary. For example, it can be used alongside newer agents such as SGLT-2 inhibitors or DPP-4 inhibitors to achieve even better blood sugar control in patients who need additional therapeutic options.

Side Effects of Gliclazide Metformin (SR) Tablet

Like all medications, PCD Franchise for Gliclazide Metformin (SR) Tablets can cause side effects, though not everyone will experience them. It is important to be aware of the possible side effects, both common and rare:

Common Side Effects:

Hypoglycemia (Low Blood Sugar): Gliclazide, a sulfonylurea, can cause hypoglycemia, particularly when meals are missed or if combined with other glucose-lowering agents like insulin. Symptoms of hypoglycemia include sweating, dizziness, shaking, hunger, confusion, and palpitations.

Gastrointestinal Issues: Metformin can cause gastrointestinal disturbances, particularly during the first few weeks of treatment. Common symptoms include nausea, vomiting, diarrhea, abdominal discomfort, and bloating. These side effects often improve as the body adjusts to the medication.

Headache: Some patients may experience headaches as a side effect of Gliclazide Metformin (SR) tablets, though this is usually mild and temporary.

Dizziness: Dizziness or lightheadedness may occur, particularly in patients with low blood sugar or those adjusting to the medication.

Serious Side Effects:

Lactic Acidosis: A rare but serious side effect of Metformin is lactic acidosis, a condition where lactic acid builds up in the blood. This can occur in patients with kidney or liver dysfunction. Symptoms include weakness, muscle pain, difficulty breathing, and abdominal pain. Immediate medical attention is required if these symptoms occur.

Coordination Problems: Some individuals may experience difficulties with motor coordination or balance, which can increase the risk of falls or accidents.

Allergic Reactions: Some individuals may experience allergic reactions to the medication, such as skin rashes, itching, swelling of the face or throat, and difficulty breathing. This requires prompt medical intervention.

Blood Disorders: In rare cases, Gliclazide can cause changes in blood counts, such as thrombocytopenia (low platelet count), leukopenia (low white blood cell count), or hemolytic anemia. Routine blood tests may be required to monitor this.

Long-term Risks:

Vitamin B12 Deficiency: Long-term use of Metformin can interfere with the absorption of Vitamin B12, potentially leading to a deficiency. Regular monitoring and supplementation may be necessary.

Precautions and Interactions

Before starting Pharma Franchise for Gliclazide Metformin (SR) Tablets , certain precautions should be considered:

Renal Impairment: Patients with kidney problems should use this medication cautiously, as Metformin can increase the risk of lactic acidosis in those with reduced kidney function.

Liver Disease: Patients with liver impairment should avoid Metformin due to the increased risk of lactic acidosis.

Pregnancy and Breastfeeding: Gliclazide Metformin (SR) should not be used during pregnancy or breastfeeding unless prescribed by a healthcare provider.

Alcohol Consumption: Alcohol increases the risk of hypoglycemia and lactic acidosis when combined with this medication, so it should be consumed in moderation or avoided.

Conclusion | Pharma Franchise Company for Gliclazide Metformin (SR) Tablets

In conclusion, Pharma Franchise Company for Gliclazide Metformin (SR) Tablets is a highly effective combination therapy for managing Type 2 diabetes, offering dual action on insulin secretion and insulin sensitivity. With its sustained-release formulation, it provides extended blood sugar control and reduces the risk of complications associated with diabetes. However, like all medications, it requires careful monitoring for side effects and interactions.

 

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