GLIMLASE-M1

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GLIMLASE-M1

Brand Name : GLIMLASE-M1

Packing : 10*15

Composition : Bilayered Tablet of Metformine(SR)500mg + Glimepiride 1mg Tablet

GLIMLASE-M1

 


 

Bilayered Metformin Glimepiride Tablet: Overview

A bilayered Metformin-Glimepiride tablet is a combination oral hypoglycemic medication designed to manage Type 2 diabetes mellitus. It includes two active ingredients: Metformin and Glimepiride. These drugs work together to improve blood sugar control in individuals with Type 2 diabetes. The bilayered design offers a sustained and controlled release of the active ingredients, maximizing the therapeutic benefits while minimizing side effects.

Metformin: Metformin belongs to a class of drugs called biguanides. It primarily reduces blood glucose levels by decreasing the production of glucose in the liver (hepatic gluconeogenesis) and improving insulin sensitivity in the muscles and fat tissues. Metformin is considered the first-line treatment for most patients with Type 2 diabetes, particularly those who are overweight, because it helps with weight control and has a favorable cardiovascular profile.

Glimepiride: Glimepiride is a sulfonylurea, a class of medications that helps to increase insulin secretion from the pancreas. It stimulates the pancreatic beta cells to produce more insulin, thus helping to lower blood sugar levels. While sulfonylureas can be effective in controlling blood glucose, they come with risks such as hypoglycemia (low blood sugar) and weight gain.

By combining these two agents in a bilayered Metformin-Glimepiride tablet form, healthcare providers can achieve more stable blood glucose control with potentially fewer side effects.

Mechanism of Action of Bilayered Metformin-Glimepiride Tablet

Metformin Action:

1. Reduces glucose production in the liver.
2. Enhances insulin sensitivity, improving glucose uptake in peripheral tissues (muscle and adipose tissue).
3. Does not stimulate insulin production, hence carries no risk of hypoglycemia when used alone.
4. Reduces absorption of glucose from the intestines.

Glimepiride Action:

1. Stimulates the pancreas to release insulin, particularly in response to meals.
2. Increases insulin receptor sensitivity on muscle and fat cells, thereby promoting glucose uptake.
3. The bilayered formulation allows the two drugs to be released at different rates. This is designed to provide a more stable and sustained glycemic control.
4. The quick-release layer usually contains Glimepiride to manage post-meal blood glucose spikes, while the slow-release layer contains Metformin, which works over time to manage fasting blood glucose levels and maintain overall glycemic stability.

Uses of Bilayered Metformin-Glimepiride Tablet

The primary use of the Pharma Franchise for Bilayered Metformin-Glimepiride Tablet is for the management of Type 2 diabetes mellitus. It is prescribed to:

1. Patients whose blood sugar levels are not adequately controlled by Metformin alone.

2. Individuals who need dual therapy to enhance glycemic control.

3. Patients who are at risk of complications related to insulin resistance and elevated blood sugar levels.

4. Doctors typically prescribe this medication alongside lifestyle changes like diet modification and exercise to achieve optimal glycemic control.

5. The combination is effective for individuals who are at an increased risk of developing diabetes-related complications such as cardiovascular disease, neuropathy, nephropathy, and retinopathy.

Benefits of Bilayered Metformin-Glimepiride Tablet

Enhanced Glycemic Control:

By combining two different classes of anti-diabetic agents, this medication offers more comprehensive blood glucose control.

Metformin targets fasting blood glucose, while Glimepiride helps to manage postprandial (post-meal) blood sugar spikes.

Convenience: Taking one combination tablet instead of two separate medications improves patient compliance. The bilayered tablet provides sustained release, potentially reducing the need for multiple doses throughout the day.

Weight Management: Metformin is known to support weight loss or at least weight stabilization, which is beneficial for patients with Type 2 diabetes who are often overweight. Though Glimepiride may lead to slight weight gain, the combination with Metformin can help balance this effect.

Cardiovascular Benefits: Metformin has demonstrated cardiovascular protective effects in multiple studies. It helps in reducing LDL cholesterol and triglycerides, improving cardiovascular outcomes.

Cost-Effectiveness: Combination therapy is often more economical for patients compared to purchasing two separate medications, making treatment more accessible for many.

Side Effects of Bilayered Metformin-Glimepiride Tablet

Like all medications, bilayered PCD Franchise for Bilayered Metformin-Glimepiride Tablet can cause side effects. Some of these are mild, while others may require medical attention.

Common Side Effects

Hypoglycemia: Glimepiride, as a sulfonylurea, increases insulin production, which can lead to low blood sugar levels, especially if the patient skips meals or exercises excessively.

Gastrointestinal Issues: Metformin is associated with GI side effects such as nausea, diarrhea, abdominal discomfort, and bloating. These usually subside with time or with dose adjustments.

Weight Gain: Glimepiride may lead to modest weight gain, although this is generally offset by Metformin.

Fatigue or Dizziness: Some patients may experience feelings of fatigue or dizziness, especially if their blood sugar drops too low.

Serious Side Effects

Lactic Acidosis: A rare but potentially serious side effect of Metformin is lactic acidosis, a buildup of lactic acid in the bloodstream. This condition is more likely in patients with kidney problems, dehydration, or those taking excessive doses of the drug.

Severe Hypoglycemia: Glimepiride can cause significant drops in blood sugar, especially if combined with other hypoglycemic agents like insulin or if the patient is fasting.

Allergic Reactions Patients may also experience allergic reactions such as:
1. Skin rash
2. Itching
3. Swelling (especially of the face, tongue, or throat)
4. Severe dizziness
5. Difficulty breathing

It is essential for patients to inform their healthcare provider if they experience any serious or persistent side effects.

Medicines and Drug Interactions

Several medications can interact with the Pharma Franchise for Bilayered Metformin-Glimepiride Tablet , either increasing or decreasing its effectiveness, or raising the risk of side effects.

Insulin or Other Antidiabetic Medications:

1. When used with insulin or other hypoglycemics, this combination may cause excessive blood sugar reduction, leading to hypoglycemia.

2. Diuretics (e.g., Furosemide):

3. Diuretics can increase blood sugar levels, reducing the effectiveness of this combination.

4. ACE Inhibitors:

5. Drugs such as Lisinopril may enhance the blood glucose-lowering effects of the combination, raising the risk of hypoglycemia.

5. Drugs such as Lisinopril may enhance the blood glucose-lowering effects of the combination, raising the risk of hypoglycemia.

Beta-Blockers: Medications like Propranolol can mask some symptoms of hypoglycemia, such as a rapid heartbeat, making it harder for patients to recognize low blood sugar.

Corticosteroids and Oral Contraceptives: These drugs can counteract the blood glucose-lowering effects of the tablet, making diabetes harder to manage.

Conclusion | PCD Franchise for Bilayered Metformin-Glimepiride Tablet

Pharma Franchise Company for Bilayered Metformin-Glimepiride Tablet - Bilayered Metformin-Glimepiride tablets are a powerful tool for managing Type 2 diabetes, offering comprehensive blood glucose control through a combination of mechanisms. The formulation provides enhanced patient compliance, sustained glycemic management, and potential cardiovascular benefits, making it a valuable option for many diabetic patients. However, it is essential to monitor for side effects like hypoglycemia and lactic acidosis and consider potential drug interactions that may impact treatment efficacy.

 

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